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大豆異黃酮納米粉體的反溶劑法制備及表征

發(fā)布時(shí)間：2019/11/4 15:57:25     瀏覽次數(shù)：1164

大豆異黃酮納米粉體的反溶劑法制備及表征
Preparation and Characterization of Soy Isoflavone Nanoparticles by Antisolvent Precipitation Method
  
DOI：
中文關(guān)鍵詞: 大豆異黃酮  微細(xì)粉體  反溶劑  表征  粒徑

英文關(guān)鍵詞: soy isoflavone  powder  anti-solvent  characterization  particle size

以二甲基亞砜作為溶劑，丙酮為反溶劑制備大豆異黃酮納米粉體。通過正交試驗(yàn)設(shè)計(jì)法，以大豆異黃酮粒徑為指標(biāo)，對(duì)各個(gè)影響因素和水平進(jìn)行研究，得到最佳的試驗(yàn)條件。結(jié)果：大豆異黃酮的納米粒徑與溶液體積比、勻漿器轉(zhuǎn)速、溶液濃度呈反比，與反應(yīng)時(shí)間呈正比。大豆異黃酮的最佳試驗(yàn)條件為：溶液質(zhì)量濃度300 mg/mL，轉(zhuǎn)速1 200 r/min，溶劑與反溶劑的體積比1∶6，反應(yīng)時(shí)間3 min。在該條件下得到的納米大豆異黃酮粒徑為98 nm。通過掃描電鏡（SEM）觀測粒子外觀，并用粉體堆密度方法統(tǒng)計(jì)。通過紅外光譜（FT-IR）、差熱掃描（DSC）等方法對(duì)制備的粉體進(jìn)行物理化學(xué)性質(zhì)表征。結(jié)果表明：制備前、后大豆異黃酮的粉體化學(xué)性質(zhì)沒有發(fā)生改變，納米大豆異黃酮顆粒分布均勻，粒徑顯著減小。

Taking dimethyl sulfoxide as solvent， soy isoflavone powder was prepared by acetone as the anti-solvent. Orthogonal experimental design method was used to in spect the major factors affecting the size and morphology of soy isoflavone powder. Results show that the particle size has a negative relationship with volume ratio， rotor speed and concentration， and has a positive relationship with reaction time. Experiment indicates that the measured powder particle size reaches 98 nm when the concentration is 300 mg/mL； rotor speed is 1 200 r/min； volume ratio is 1 ∶ 6 and reaction time is 3 min. Isoflavone and nano-isoflavone power were evaluated by using scanning electron microscope （SEM）， infrared spectroscopy （FT-IR）， differential scanning calorimetry （DSC） and statistics of powder heap density. Results showed that the chemical properties of isoflavones did not change after preparation. Nano-isoflavone particles were distributed evenly and the particle size decreased significantly.